Connecting People.
Accelerating Research.

Our mission is to unite LMNA experts, key opinion leaders, and patients in order to accelerate research and development, aiming to discover an effective treatment for LMNA-related cardiac diseases.

LMNA Cardiac Diseases Network

Welcome to LMNAcardiac.org, your gateway to the latest in LMNA cardiac diseases. This platform unites patients, medical professionals, researchers, and industry innovators, creating a vibrant community dedicated to advancing our understanding and treatment of LMNA-related heart conditions.

What is LMNA?

LMNA is a gene that produces proteins essential for cell structure and stability. Mutations in the LMNA gene can lead to various diseases by disrupting normal cell structure and function.

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LMNA Diseases By The Numbers

90%
Penetrance Rate
Generally speaking, LMNA-related DCM demonstrates age-related penetrance with onset in the third and fourth decades (20's and 30's), so that by the seventh decade (60's) penetrance is considered greater than 90%.
source
50%
Familial Transmission Rate
There is a 50% chance of passing the LMNA variant to offspring in autosomal dominant inheritance patterns, emphasizing the importance of genetic  testing for families affected by LMNA.
source
10%
Prevelance in Familial DCM
Variants in the LMNA gene account for up to 5% of DCM cases; however, its prevalence increases up to 10% in familial DCM and up to 33% in DCM associated to atrioventricular conduction disorders.
source

Common Conditions

Dilated Cardiomyopathy
A condition where the heart's ability to pump blood is decreased due to an enlarged and weakened left ventricle, often associated with LMNA mutations.
Conduction Disorder & Arrhythmias
LMNA often leads to conduction disorders and arrhythmias, causing irregular heart rhythms and requiring medical attention including implanting a defibrillator.
Muscular Dystrophy
Characterized by progressive muscle weakness and wasting, often accompanied by cardiac issues, due to mutations in the LMNA gene.

The Warning Signs

Family History of Heart Disease
Particularly if relatives have been diagnosed with dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, or sudden cardiac death at a young age.
Cardiac Symptoms
Unexplained heart-related symptoms, such as irregular heartbeats, palpitations, fainting spells, or unexplained fatigue, especially if these symptoms occur at a young age.
Muscular Symptoms
In some cases, symptoms related to muscle weakness or wasting, particularly in the upper arms and thighs, which may indicate a condition like Emery-Dreifuss muscular dystrophy.

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About LMNA diseases
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Living with LMNA Variants
Explore guidance and insights on navigating life with LMNA diseases.
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Patient Resources
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Every contribution, regardless of its amount, fuels crucial efforts in research, medical education, patient advocacy, and raising awareness about LMNA cardiac diseases.

You can make a difference in various ways: by committing as a regular monthly donor, offering a single donation, organizing fundraising events both online and in person, contributing to our special tribute funds, or through your unique fundraising initiatives!
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